From Club release:
| DATE | OPPONENT | Venue | TIME (CT) |
| Sun., Feb. 27, 2022 | Seattle Sounders FC | Lumen Field | 7:00 p.m. |
| Sat., Mar. 5, 2022 | Minnesota United FC | Allianz Field | 5:00 p.m. |
| Sat., Mar. 12, 2022 | FC Dallas | Toyota Stadium | 7:30 p.m. |
| Sat., Mar. 19, 2022 | Real Salt Lake | Rio Tinto Stadium | 8:30 p.m. |
| Sat., Apr. 2, 2022 | Columbus Crew | Lower.com Field | 5:00 p.m. |
| Sat., Apr. 9, 2022 | Sporting Kansas City | Children’s Mercy Park | 7:30 p.m. |
| Sat., Apr. 16, 2022 (Univision) | San Jose Earthquakes | PayPal Park | 2:30 p.m. |
| Sat., Apr. 23, 2022 | LA Galaxy | Dignity Health Sports Park | 9:30 p.m. |
| Sun., May 1, 2022 (ESPN) | Philadelphia Union | Nashville SC Stadium | 3:00 p.m. |
| Sun, May 8, 2022 | Real Salt Lake | Nashville SC Stadium | 4:00 p.m. |
| Sat., May 14, 2022 | Houston Dynamo FC | PNC Stadium | 7:30 p.m. |
| Wed., May 18, 2022 | CF Montreal | Nashville SC Stadium | 7:30 p.m. |
| Sat., May 21, 2022 (FOX) | Atlanta United FC | Nashville SC Stadium | 6:30 p.m. |
| Sat., May 28, 2022 | Colorado Rapids | Dick’s Sporting Goods Park | 8:00 p.m. |
| Sat., June 11, 2022 (UniMas) | San Jose Earthquakes | Nashville SC Stadium | 5:00 p.m. |
| Sun., June 19, 2022 (FS1) | Sporting Kansas City | Nashville SC Stadium | 5:00 p.m. |
| Sat., June 25, 2022 (ESPN) | D.C. United | Audi Field | 4:00 p.m. |
| Sun., July 3, 2022 | Portland Timbers | Nashville SC Stadium | 7:30 p.m. |
| Sat., July 9, 2022 (FS1) | Charlotte FC | Bank of America Stadium | 6:00 p.m. |
| Wed., July 13, 2022 | Seattle Sounders FC | Nashville SC Stadium | 7:30 p.m. |
| Sun., July 17, 2022 | LAFC | Nashville SC Stadium | 7:30 p.m. |
| Sat., July 23, 2022 | FC Cincinnati | TQL Stadium | 6:30 p.m. |
| Sat., July 30, 2022 | Vancouver Whitecaps | Nashville SC Stadium | 7:00 p.m. |
| Wed., Aug. 3, 2022 | Portland Timbers | Providence Park | 9:30 p.m. |
| Sat., Aug. 6, 2022 | Toronto FC | Nashville SC Stadium | 7:00 p.m. |
| Sun., Aug. 14, 2022 (FS1) | Minnesota United FC | Nashville SC Stadium | 7:00 p.m. |
| Sun., Aug. 21, 2022 | FC Dallas | Nashville SC Stadium | 7:30 p.m. |
| Sat., Aug. 27, 2022 | Vancouver Whitecaps | BC Place | 9:00 p.m. |
| Wed., Aug. 31, 2022 | Colorado Rapids | Nashville SC Stadium | 7:30 p.m. |
| Sat., Sept. 3, 2022 | Austin FC | Nashville SC Stadium | 7:30 p.m. |
| Sat, Sept. 10, 2022 (Univision) | LA Galaxy | Nashville SC Stadium | 2:30 p.m. |
| Sat, Sept 17, 2022 | Austin FC | Q2 Stadium | 8:00 p.m. |
| Sun, Oct. 2, 2022 | Houston Dynamo FC | Nashville SC Stadium | 7:30 p.m. |
| Sun, Oct. 9, 2022 | LAFC | Banc of California Stadium | 4:00 p.m. |
More analysis to come.
Club and Country 